AI-supported reading in the MASAI mammography trial
The MASAI trial in Sweden randomly assigned screening mammograms to AI-supported reading or standard double reading without AI. Transpara scored each exam and routed lower scores to a single reader and the highest score to double reading, with detection marks available on higher-risk exams. This card quotes the prespecified interim safety analysis, not a claim that every screening program should switch.
Clinical setting
Population mammography screening for women aged 40–80 at four sites in southwest Sweden, inside the existing screening invitation.
Tools and vendors
Transpara 1.7.0
ScreenPoint Medical
What was reported
In the interim analysis of about 80,000 women (Lancet Oncology, 2023), cancer detection was 6.1 per 1,000 with AI support and 5.1 per 1,000 with standard reading (ratio 1.2, p=0.052). False-positive rates were 1.5% in both arms. Screen-reading workload fell by 44.3%. Interval cancer, the primary endpoint, was left to later follow-up.
Source
Lång et al., The Lancet Oncology · Aug 1, 2023 · Year 2023
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LumineticsCore (IDx-DR) · Digital Diagnostics · Topcon NW400
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