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TREWS sepsis early warning on the inpatient ward

ОпубликованоСтатья

Текст показан по-английски, пока нет перевода.

The source is Adams and colleagues, Nature Medicine, 21 July 2022, a prospective evaluation of TREWS across five hospitals. It reports that, among patients with sepsis identified before antibiotics, confirmation of the alert within 3 hours was associated with an adjusted absolute mortality difference of 3.3 percentage points (relative 18.7%) versus alerts not confirmed in that window. A companion paper reported a 1.85-hour shorter median time to the first antibiotic order for the same comparison. These are associations with how the alert was used, not a randomized trial.

Source date
21 июл. 2022 г. · Год 2022
Evidence label
Опубликовано
Source type
Статья

Citation

Adams et al., Nature Medicine

Adams et al. Prospective, multi-site study of patient outcomes after implementation of the TREWS machine learning-based early warning system for sepsis. Nature Medicine, 21 July 2022. https://www.nature.com/articles/s41591-022-01894-0

Key public facts

  • TREWS was studied prospectively in emergency departments and wards at two academic and three community hospitals.
  • A clinician confirms or dismisses the alert. The system does not itself diagnose sepsis.
  • Among patients with sepsis identified before antibiotics, confirmation within 3 hours was associated with an adjusted absolute mortality difference of 3.3 percentage points (relative 18.7%) versus alerts not confirmed in that window.
  • A companion paper reported a 1.85-hour shorter median time to the first antibiotic order for that same comparison.
  • The paper reports associations with how the alert was used. It is not a randomized trial of the model.
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