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External validation of a widely deployed sepsis model

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此語言的正文尚未翻譯,暫以英文顯示。

The source is Wong and colleagues, JAMA Internal Medicine, 21 June 2021, an external validation of the Epic Sepsis Model at Michigan Medicine. Across 38,455 hospitalizations the hospitalization-level AUC was 0.63 (95% CI 0.62–0.64). At a score of 6 or higher the model alerted on 18% of hospitalizations, did not identify 67% of sepsis cases, and found only 7% of sepsis patients who had not already received timely antibiotics. The paper is a caution about local validation of a widely deployed proprietary score.

來源日期
2021年6月21日 · 年份 2021
證據標籤
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來源類型
論文

完整引用

Wong et al., JAMA Internal Medicine

Wong et al. External validation of a widely implemented proprietary sepsis prediction model in hospitalized patients. JAMA Internal Medicine, 21 June 2021. https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2781307

已公開的關鍵事實

  • The study covers 38,455 adult hospitalizations at Michigan Medicine. The score was recalculated through the stay.
  • Sepsis was defined from surveillance criteria and the record, not from the model’s own label.
  • The hospitalization-level AUC was 0.63 (95% CI 0.62–0.64), below the discrimination the developer had reported.
  • At a score of 6 or higher the model alerted on 18% of hospitalizations and did not identify 67% of sepsis cases.
  • It found only 7% of sepsis patients who had not already received timely antibiotics.
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